It is known that, in hepatosis, toxins affect not only the liver, but also all the internal organs and the central nervous system. Subacute hepatosis was modelled in rats in laboratory conditions, followed by treatment with polyprenols in different doses. Blood and liver indicators improved in the animals, a psycho-activating effect on the brain was observed, as well as other positive effects. As a result, it was concluded that polyprenols have a pronounced hepatoprotective and neuroprotective effect in the wide range of doses.
A story of a female patient who managed to restore her brain activity within 1 year of treatment with a polyprenolic preparation. The story began with a "cold", after which confusion, anxiety, forgetfulness, insomnia and headaches started to develop. Some time later, the patient fell into a coma, disorders in the internal organs were observed. After emerging from the coma, the patient lost the ability to communicate properly, could not attend to herself, suffered from mental disorders. She was admitted to a psychiatric hospital with the following diagnosis: "Encephalopathy with the primary injury of the left hemisphere". Treatment with polyprenols in conjunction with conventional therapy started immediately upon admission to the hospital, and consciousness recovered within a few weeks, and there was a significant reduction of lesions in the brain within a couple of months. A year later there were no regressions, the patient felt well and was fully functional.
D.V. Faddeev, V.G. Agishev, N.S. Sluchevskaya I.I. Skvortsov-Stepanov City Psychiatric Hospital No. 3; Saint Petersburg; Russia
Polyprenols are a vegetable counterpart of the endogenous transport lipid (dolichol) that provides the reactions of glycosylation during the synthesis of glycoproteins. It is proven that polyprenols show an expressed hepatoprotective action and are a brain protector to a lesser extent. Female patient A., date of birth 1961, was treated in I.I. Skvortsov-Stepanov City Psychiatric Hospital No. 3 from 27 May 2009 through 14 August 2009
Not hereditarily tainted. Secondary education. She worked as a pre-school teacher. She had 3 children. She was kind, soft, and industrious by nature. She had no serious somatic diseases previously. She was not alcoholized, she did not smoke. She had no mental disorders till April 2009. In April 2009, she had a "cold-related disease" (runny nose, cough, headache), but continued to work. However, since the end of April, she had increasing confusion, anxiety, forgetfulness, insomnia and headaches. She was medically checked and was first placed in the regional somatic hospital with a diagnosis of "progressive multifocal encephalopathy", where she had symptomatic therapy. It is also noted that a pathogenetic therapy for this pathology does not exist. She was further transferred to a district hospital, where symptoms of impaired consciousness, sopor, coma, in the test results – leukopenia, anemia appeared. On the CT scan of internal organs there were hydropericardium, hydrothorax, hepatomegaly, ESR reached 53 mm/h. On the ECG dated 08 May 2009 there were disorders of processes of repolarization of myocardium of diffuse nature. After the improvement of somatic condition, there was a worsening of the mental condition: symptoms of amentia, anxiety appeared, and therefore she was transferred to I.I. Skvortsov-Stepanov City Psychiatric Hospital No. 3. The mental state when admitted to Psychiatric Hospital No. 3 on 28 May 2009: the consciousness was impaired with the amentive type, anxious "field" behavior. There was a sensory and motor aphasia. Self-service skills were impaired. In the neurological status since 02 June 2009: there is no contact with the patient because of speech disorders, she performs no instructions, insignificant organic symptoms are observed: flatness of the right nasolabial fold, a positive Barre test on the right. Tendon and periosteal reflexes are higher on the right, apraxia. Diagnosis: "Encephalopathy with the primary injury to the left hemisphere".
Blood tests when admitted on 29 May 2009: leukopenia, anemia, ESR 35 mm/h. Blood biochemistry test of 29 May 2009: the increase of AST, sugar in the blood serum and cholesterol. MRI of 28 April 2009 (before treatment): inactive edge accumulations of the contrast agent in the lesions in the temporal, frontal, parietal lobes. Pathological formations are located in the white matter of both hemispheres of the brain, with no signs of perifocal edema. Conclusion: progressive multifocal encephalopathy can be considered. After the treatment, the mental state as of 05 July 2009: the consciousness is restored completely. Sensory and motor aphasias disappeared, the asthenic syndrome and faintheartedness were observed.
A neurological examination dated 26 July 2009: a regress of focal symptoms. A psychological examination dated 26 June 2009: a disorder in the form of progressive intellectual-mnestic failure with the intensely increasing disorders of speech, reading and writing, counting, gnosis and praxis. A psychological examination dated 05 September 2009: concrete thinking, sufficient practical orientation, IQ was 92 by the Wechsler scale, asthenic syndrome, MRI dated 27 July 2009: noticeable positive dynamics in the form of a reduction of the number and sizes of the zones of the pathological signal in the hemispheres of the brain. Conclusion: "Pattern of disseminated encephalomyelitis". A year later, MRI dated 28 September 2010: MRI pattern dated 27 July 2009 without noticeable dynamics. Most likely, it is "disseminated encephalomyelitis, latent period". Treatment: along with the common symptomatic therapy (cerepro, mexidol, vinpocetine, gliatilin intravenously and orally, akatinol-memantine, repolarizing solutions, egilok, chlorprothixene), the patient took a polyprenolic preparation* since the first days in the following doses: at first 8 drops 3 times a day, subsequently 4 drops 3 times a day and 3 drops 3 times a day. She continued to take this preparation during the whole year of the observation (till September 2010).
The patient recover from psychosis with sufficient criticism, with the amnesia of the first month of stay in the hospital. She is now fully functional, emotionally safe, is going to get herself a job.
*A polyprenolic preparation of Ropren was used the study, which is a pure concentrate of polyprenols (the total fraction is 95%). The text of the study is provided by courtesy of Solagran.